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Case Study: VEXAS Syndrome

vexas disease- Bone Marrow Aspirate NEJM

Background VEXAS syndrome is a disease with inflammatory and hematologic (blood) manifestations. The syndrome is caused by mutations in the UBA1 gene affecting the Met41 residue of the protein and resulting in decreased cellular ubiquitylation activity and hyperinflammation. This is an adults-onset fatal disease that may present as myelodysplastic syndrome, aplastic anemia or multiple myeloma, but characterized […]

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What are some of the hematologic manifestations of VEXAS syndrome?

What are some of the hematologic manifestations of VEXAS syndrome?

A Man with a Recurrent Left Pleural Effusion In late 2020, a new disease entity that was referred to as VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome was reported. Q: What is the cause of VEXAS syndrome?A: VEXAS syndrome is caused by somatic mutations in UBA1 (the gene that encodes ubiquitin-like modifier activating enzyme 1), which initiates […]

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GTC scientists contribute to major study published in Journal of Clinical Oncology: Prediction of outcome in CLL patients

GTC scientists contribute to major study published in Journal of Clinical Oncology: Prediction of outcome in CLL patients

GTC scientists collaborate with the NIH on a study just published in the Journal of Clinical Oncology. The publication is titled: Prediction of outcome in CLL patients treated with ibrutinib: development and validation of a four-factor prognostic model. You can read the article here (subscription required). Abstract: PURPOSE Randomized trials established the superiority of ibrutinib-based […]

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Utilize the first AI software for diagnosing DLBCL

Utilize the first AI software for diagnosing DLBCL

GTC is the first and only diagnostic lab to deploy true artificial intelligence (AI) software for classifications of lymphoma. Do not accept partial results, send your lymphoma to GTC for comprehensive classification using RNA/DNA and artificial intelligence. Get results in 7 days for DNA and 10 days for RNA GTC was recently published in Blood […]

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Hackensack Meridian Health Partners with GTC to Establish a Reference Laboratory Offering State-of-the-Art Genomic Precision Testing

Hackensack Meridian Health Partners with Genomic Testing Cooperative to Establish a Reference Laboratory Offering State-of-the-Art Genomic Precision Testing

IRVINE, Calif. and EDISON, N.J., July 22, 2020 /PRNewswire/ — Hackensack Meridian Health (HMH) in Edison, New Jersey, and Genomic Testing Cooperative (GTC), Irvine, California, announced today an agreement to establish a next generation sequencing reference laboratory for molecular profiling. The state-of-the-art laboratory, located at JFK Medical Center in Edison, New Jersey, will use artificial intelligence […]

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