Solid Tumor Profile

The Solid Tumor Profile is designed to analyze the molecular abnormalities of DNA in various solid tumors including cancers of the lung, pancreas, brain, colon, breast, ovary, endometrium, thyroid, head and neck, and soft tissue (sarcoma and GIST). GTC always recommends adding RNA analysis to our Solid Tumor Profile to provide a complete answer. RNA helps provide additional clinically actionable information on fusions, gene expression, mutations immunophenotyping, and more. 

The Solid Tumor Profile provides physicians with clinically actionable information.  This profiling covers abnormalities in single-nucleotide and indels in 434 genes. All exons of the 434 genes are covered and evaluated for abnormalities.  In addition, the test is designed to detect microsatellite instability (MSI), tumor mutation burden (TMB) and homologous recombination deficiency (HRD).  Significant amplification in various genes can also be detected and reported.  The provided information helps in determining prognosis, designing a therapeutic approach and predict response to therapy.

MGMT methylation assay is available as an add on for brain cancer patients. MGMT methylation is predictive of response to radiotherapy and prognostic for glioblastoma.

Turn Around Time5-7 days

GTC uses AI in every step of our analysis and it makes a difference in helping make a new discovery daily that improves patient care.

Once the data is offloaded from the sequencer, our AI:

  1. Assists with mutation analysis, identifying non-mutations and artifacts
  2. Compares various data sets to explore disease biology
  3. Provides support for clinical decision-making and classification of the disease
  4. It helps with matching patients to therapeutics and presents clinical trial options
  5. Aggregates data for report generation and simplifies the results so they are easily understood
    • FFPE: 1 H&E slide and 6-8 unstained slides, 5-7 microns of tissue fixed with 10% NBF fixative. Please circle tumor for microdissection. Alternatively, the FFPE block can be sent for tumor circling and cutting at our laboratory.
    • Complete requisition, making sure all sections are completed in their entirety including client information, patient Information, specimen Information and test selection. Missing information may delay reporting of test results.
    • Diagnosis/patient history is extremely important in rendering the correct interpretation of results and should also be filled out as completely as possible.
    • A copy of a path report should be included.
    • Ensure the specimen is labeled with patient name and number. A minimum of two patient identifiers is required for each specimen. 

Specimen Preparation and Shipping Guidelines

Use Solid Tumor Transport Kit

  • Complete Requisition, making sure all sections are completed in their entirety including client information, patient Information, specimen Information and test Selection.  Missing information may delay reporting of test results.
  • Diagnosis/patient history is extremely important in rendering the correct interpretation of results and should also be filled out as completely as possible. A copy of a Path report should be included.
  • Ensure the specimen is labeled with patient name and number.  A minimum of two patient identifiers is required for each specimen

For FFPE samples:

  • If sending FFPE Block-Insert up to 6 blocks into plastic block tray provided. Insert block tray into foam insert in the transport box.
  • If sending slides-Insert slides into plastic slide holders provided. Insert the slide holders into the foam insert in the transport box.  The container will hold up to 6 maximum slide holders.
  • Place folded test requisition(s) and/or manifest(s) if ordered electronically into the transport kit. 
  • Close box and tuck tabs into place. No tape necessary. 

Request Kits

Fill out the form below to request kits. Please refer to the Specimen Requirements page for more details.
*GTC will need to set you up in our system if this is your first order.

Genes validated and tested for Mutations in DNA testing for Solid Tumor

(* Microsatellite markers BAT25, BAT26, D2S123, D5S346, and D17S250 are included.)

 

How to complete the Genomic Testing Cooperative requisition form.

Download our
Test Requisition

Keep in mind that we do not accept blood samples directly from individuals. Talk with your M.D. to fill out the form for you.

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Solid Tumor Profile