Innovation in Next Generation Sequencing

Making Genomics Available and Affordable for Everyone

Solid Tumor Fusion/Expression Profile

This test provides clinically relevant information on translocations and expression of cancer-specific genes. This assay is designed to detect various translocations involving more than 60 genes, including ALK, ROS1, RET, NTRK1, NTRK2, NTRK3, BRAF, CIC, EWSR1, PD-L1, and others. This also covers screening for sarcoma translocations and aids in sarcoma diagnosis and classification. In addition, the expression of genes of clinical relevance is reported including MYC, PD-L1, and others.

Turn Around Time: 7-10 days

  • FFPE: 1 H&E slide and 6-8 unstained slides, 5-7 microns of tissue fixed with 10% NBF fixative. Please circle tumor for microdissection. Alternatively, the FFPE block can be sent for tumor circling and cutting at our laboratory

Specimen Preparation and Shipping Guidelines

Use Solid Tumor Transport Kit

  • Complete Requisition, making sure all sections are completed in their entirety including client information, patient Information, specimen Information and test Selection.  Missing information may delay reporting of test results.
  • Diagnosis/patient history is extremely important in rendering the correct interpretation of results and should also be filled out as completely as possible. A copy of a Path report should be included.
  • Ensure the specimen is labeled with patient name and number.  A minimum of two patient identifiers is required for each specimen

For FFPE samples:

  • If sending FFPE Block-Insert up to 6 blocks into plastic block tray provided. Insert block tray into foam insert in the transport box.
  • If sending slides-Insert slides into plastic slide holders provided. Insert the slide holders into the foam insert in the transport box.  The container will hold up to 6 maximum slide holders.
  • Place folded test requisition(s) and/or manifest(s) if ordered electronically into the transport kit. 
  • Close box and tuck tabs into place. No tape necessary. 
 

Genes validated and tested for Mutations in DNA testing for Solid Tumor

ABCB7DDX41IGF2PIK3C2BTCIRG1
ABL1DKC1IKBKEPIK3CATERC
ABL2DNM2IKZF1PIK3CBTERF1
ACDDNMT3AIKZF3PIK3CGTERF2
ACVR1BDICER1IL2RGPIK3R1TERF2IP
ADADOT1LIL7RPIK3R2TERT
AK2EEDINHBAPIM1TET2
AKT1EGFRINPP4BPLCG1TGFBR2
AKT2EGLN1IRF2PLCG2TNFAIP3
AKT3ELANEIRF4PMS1TNFRSF14
ALKEP300IRS2PMS2TNFRSF1A
AMER1EPAS1JAGN1POLD1TOP1
ANKRD26EPCAMJAK1POLETOP2A
APCEPHA3JAK2POT1TP53
AREPHA5JAK3PPM1DTRAF3
ARAFEPHA7JUNPPP2R1ATSC1
ARFRP1EPHB1KAT6APRDM1TSC2
ARID1AERBB2KDM5APREX2TSHR
ARID1BERBB3KDM5CPRKAR1AU2AF1
ARID2ERBB4KDM6APRKCIU2AF2
ASXL1ERCC4KDRPRKDCVEGFA
ATG2BERGKEAP1PRSS1VHL
ATMERRFI1KELPRSS8WAS
ATRESR1KIF23PSTPIP1WHSC1
ATRXETV6KITPTCH1WISP3
AURKAEXO1KLF1PTENWT1
AURKBEZH2KLHL6PTPN11XPO1
AURKCFAM175AKLLNQKIXRCC2
AXIN1FAM46CKMT2ARAB27AXRCC3
AXIN2FANCAKMT2BRAC1ZBTB2
AXLFANCCKMT2CRAD21ZNF217
B2MFANCD2KMT2DRAD50ZNF703
BAP1FANCEKRASRAD51ZRSR2
BARD1FANCFLIG4RAD51B
BCL2FANCGLMO1RAD51C
BCL2L1FANCILPIN2RAD51D
BCL2L2FANCLLRP1BRAD54L
BCL6FANCMLYNRAF1
BCORFASLYSTRANBP2
BCORL1FAT1LZTR1RARA
BCRFBXW7MAGI2RB1
BIRC3FGF10MAP2K1RBBP6
BLMFGF14MAP2K2RBM10
BMPR1AFGF19MAP2K4RBM8A
BRAFFGF23MAP3K1RET
BRCA1FGF3MAP3K14RHEB
BRCA2FGF4MAPK1RHOA
BRD4FGF6MCL1RICTOR
BRIP1FGFR1MDM2RIT1
BTG1FGFR2MDM4RNF168
BTKFGFR3MED12RNF43
C11orf30FGFR4MEF2BROS1
C15ORF41FHMEFVRPTOR
CALRFLCNMEN1RTEL1
CARD11FLI1MergedRUNX1
CBFBFLT1METRUNX1T1
CBLFLT3MITFSBDS
CBLBFLT4MLH1SBF2
CBLCFOXL2MPLSDHA
CCND1FOXP1MRE11ASDHB
CCND2FRS2MSH2SDHC
CCND3FUBP1MSH6SDHD
CCNE1G6PC3MTORSEC23B
CD274GABRA6MUTYHSETBP1
CD79AGALNT12MVKSETD2
CD79BGATA1MYCSF3B1
CDAN1GATA2MYCLSLIT2
CDC73GATA3MYCNSLX4
CDH1GATA4MYD88SMAD2
CDK12GATA6NBNSMAD3
CDK4GEN1NF1SMAD4
CDK6GFI1NF2SMAD9
CDK8GFI1BNFE2L2SMAD9L
CDKN1AGID4NFKBIASMARCA4
CDKN1BGLI1NHP2SMARCB1
CDKN2AGLI2NKX2-1SMC1A
CDKN2BGNA11NLRP3SMC3
CDKN2CGNA13NME1SMO
CEBPAGNAQNOP10SNCAIP
CHD2GNASNOTCH1SOCS1
CHD4GPR124NOTCH2SOX10
CHEK1GREM1NOTCH3SOX2
CHEK2GRIN2ANPM1SOX9
CICGRM3NRASSPEN
CREBBPGSK3BNROB1SPOP
CRKLGSKIPNSD1SPTA1
CRLF2H3F3ANTRK1SRC
CSF1RHAX1NTRK2SRSF2
CSF3RHGFNTRK3STAG2
CTC1HIST1H3BNUP93STAT3
CTCFHNF1APAK3STAT4
CTNNA1HOXA11PALB2STAT6
CTNNB1HOXB13PARK2STK11
CUL3HRASPAX5SUFU
CUX1HSD3B1PBRM1SUZ12
CXCR4HSP90AA1PDCD1LG2SYK
CYLDID3PDGFRATAF1
DAXXIDH1PDGFRBTAL1
DDR2IDH2PDK1TBX3
DDX11IGF1RPHF6TCF3

(* Microsatellite markers BAT25, BAT26, D2S123, D5S346, and D17S250 are included.)

How to complete the Genomic Testing Cooperative requisition form.

Download our
Test Requisition

Keep in mind that we do not accept blood samples directly from individuals. Talk with your M.D. to fill out the form for you.

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