Pan-Tumor Assay for Solid Tumors
GTC’s Liquid Trace Solid Tumor is a pan-cancer highly sensitive test evaluating cfRNA and cfDNA providing highly informative data that can be used for diagnoses, evaluating the host immune response, and identifying biomarkers for predicting responses to various therapies.
GTC’s Liquid Trace Solid Tumor can significantly reduce the need for bone marrow biopsies for hematology patients, especially when obtaining tissue from the tumor is difficult.
Furthermore, Liquid Trace Solid Tumor may provide additional information not detected by tissue biopsies including information on the presence of germline mutations or mutations in the subclones not present in the tissue sample (heterogeneity).
Types of solid tumors Liquid Trace can detect:
- Oropharyngeal tumors
- Cancer of unknown primary (CUP)
Liquid biopsy in its current form is dependent on cfDNA analysis; this method likewise presents multiple challenges. These include variations in DNA shedding between tumors as well as low sensitivity (especially in early-stage cancer), difficulty in detecting fusion genes (i.e., chromosomal translocations leading to the expression of chimeric mRNA from two genes), and inability to reflect the numerous biological processes that modify RNA expression levels, such as alternative splicing, stability, and allele-specific methylation. The latter limitation is critically important as recent studies have shown that RNA testing provides another level of biological information regarding the tumor and its microenvironment.
The Benefits of cfRNA
RNA sequencing has proven to be more sensitive for some types of mutations. Cancer cells typically contain one copy of mutated DNA but numerous copies of RNA. This research is consistent with GTC’s findings that cfRNA has increased sensitivity over cfDNA alone. More specifically, cfRNA allowed GTC’s Liquid Trace to detect more mutations and fusions in hematologic and solid tumor samples, which may be undetected by conventional cfDNA.
How to complete the Genomic Testing Cooperative requisition form.
Keep in mind that we do not accept blood samples directly from individuals. Talk with your M.D. to fill out the form for you.
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