GTC-Hematology Profile Plus combines expression and fusion with mutation analysis in DNA and RNA. The test covers 177 DNA genes and 1408 RNA genes. This is a comprehensive evaluation of all hematologic neoplasms. However, it is especially recommended for:
-Acute Lymphoblastic Leukemia (ALL): This comprehensive assay is designed to confirm the diagnosis of Ph-ALL and Ph-like ALL and distinguish them from other types of ALL. It can be used for diagnosis as well as for monitoring. Ph-like ALL is detected in 20% to 25% of adult ALL and in 15% of pediatric ALL. Diagnosis of Ph+-ALL and Ph-like ALL is very important because TKI therapy can be helpful in most of these patients. This assay can determine most of the mutations, translocations, and expression of genes (CRLF2) associated with Ph+ ALL and Ph-like ALL.
-Diffuse Large B-cell Lymphoma (DLBCL) and other Lymphoma: This assay can provide very valuable information for the management and monitoring of patients with DLBCL. It can distinguish between ABC and GCB and can help in the diagnosis of double hit lymphoma. The assay is also useful for follicular lymphoma and T-cell neoplasms.
-Acute Myeloid Leukemia (AML): Translocations in AML are very important for diagnosis, prognosis and selecting therapy. This comprehensive testing can provide a complete evaluation of fusion mRNA and mutations. It also helps in determining a diagnosis in acute leukemia with ambiguous phenotype.
Clonal Hematopoiesis of Indeterminate Potential (CHIP): Distinguish CHIP from clinically active and relevant hematologic neoplasm based on an internally developed algorithm using variant allele frequency, chromosomal structural abnormalities, clinical and laboratory data and longitudinal data. This distinction is particularly important when evaluating minimal residual disease and in the presence of other neoplastic process.
IgVH Mutation Status: IgVH mutation status is very important for prognosis and selecting therapy in patients with chronic lymphocytic leukemia (CLL).
Turn Around Time: 7-10 Days
How to complete the Genomic Testing Cooperative requisition form.
Keep in mind that we do not accept blood samples directly from individuals. Talk with your M.D. to fill out the form for you.