Innovative assays that can help answer your most challenging genomic questions, comprehensively
Genomic Testing Cooperative (GTC) offers a broad range of DNA and RNA sequencing services, AI-driven software’s, analysis tools and support services for research projects and clinical trials. Our assays can be tailored to meet your clinical trial requirements and expanded upon as needed.
Therapeutic areas we have expertise:
Solid
Tumor
Hematologic
Malignancies
Liquid
Biopsy
Molecular and
Traditional IHC Assays
AI
Algorithms
Customized
Assays
How we can help you
- Analyze data from past trials to gain deeper insights of the tumor’s biology
- Use liquid biopsy to better categorize mutations from responders and non-responders
- Compare other CDx methodologies to identify alternative testing options
- Get higher quality data analyzing DNA and RNA for all tumor types
- Use liquid biopsy to monitor patients’ response to treatment
- Get multiple testing modality data like FISH, IHC, flow cytometry and cytogenetics in one assay
- Useful in multiple drug categories from immunotherapy to ADC’s
- Capable of biomarker discovery and classification
- Immune profiling of patients
- GTC’s test are fully validated and available to take through a 510k process
- GTC’s co-op network ensures multiple sites are available to run the assay
The Co-Op Network
- GTC has numerous co-op members who can be used as testing sites or trial enrollment sites.
- Assays can be transferred to any lab in the world to help support trial needs in any country.
- Leverage the power of multiple institutions for broader perspectives on testing, therapeutic implementation, data and more…
Why GTC:
- Unique menu offering numerous innovative NGS applications
- Rapid turn-around time
- Project scalability
- Robust AI and deep learning platform to help with report interpretation
- World class expertise in both hematologic cancers, solid tumors and immuno-oncology
- Access to over 40k data records
GTC’s Assays
Liquid Trace™ (cfDNA and cfRNA)
- Pan tumor assay for both solid tumors and hematologic malignancies
- Full gene sequences of 302 DNA genes and more than 1600 RNA genes
- Reliable fusion detection of both known and novel genes
- Covers numerous biomarkers like HRR, PD-L1, HER2 and more
- Includes viral DNA testing for HPV and EBV
Liquid Trace™:
Solid Tumor Profile- Indications
Chromosomal abnormalities, gene amplifications, HRR, MRD, ALK, ROS1, RET, NTRK1/2/3, BRAF, CIC, EWSR1, PD-L1, MET exon 14 skipping and various alternative splicing, MET, HER2, PIK3CA, PTEN, EGFR amplification, AKT1, RAS - Sample Type
Peripheral blood - Results Reported
DNA+RNA - Monitoring
- Therapeutic
- Prognostic
- Heterogeneity
- Clinical Trial Matching
Liquid Trace™:
Hematology Profile- Indications
Chromosomal abnormalities, gene amplifications, multiple myeloma, lymphoma, acute lymphoblastic leukemia, acute myeloid leukemia, MDS, CMML, AML, MPN, lymphoma, MRD, VEXAS syndrome, HPV, EBV - Sample Type
Peripheral blood - Results Reported
DNA+RNA - Diagnostic
- Therapeutic
- Prognostic
- Heterogeneity
- Clinical Trial Matching
Solid Tumor Profile Plus
- Pan tumor assay focused on solid tumors
- 434 DNA genes and more than 1600 RNA genes
- Covers major biomarkers like MSI, TMB, HRD and more
- Detect chromosomal structural changes
- Reliable fusion detection,
- Alternative splicing,
- Gene expression
- Exon skipping
- Immune profiling
Solid Tumor
Profile Plus™- Indications
ALK, ROS1, RET, NTRK1/2/3, BRAF, CIC, EWSR1, PD-L1, MET exon 14 skipping and various alternative splicing, MET, HER2, EGFR amplification, PIK3CA, PTEN, AKT1, RAS and HRD - Sample Type
FFPE
- - Results Reported
DNA+RNA - Diagnostic
- Therapeutic
- Prognostic
- Heterogeneity
- Clinical Trial Matching
Hematology Profile Plus
- Pan tumor assay focused on hematologic malignancies
- 179 DNA genes and more than 1600 RNA genes
- Classify all subtypes of leukemia, lymphomas, myelomas, MDS, VEXAS, CHIP and more
- AML
- CMML
- Detect chromosomal structural changes and chromosomal rearrangements
- Gene expression
Hematology
Profile Plus™- Indications
Classification and diagnosis of lymphoma, multiple myeloma, acute lymphoblastic leukemia, acute myeloid leukemia Includes IgVH mutation status - Sample Type
Bone marrow,
Peripheral blood,
Fresh tissue - Results Reported
DNA+RNA - Diagnostic
- Therapeutic
- Prognostic
- Heterogeneity
- Clinical Trial Matching
Immunohistochemistry (IHC)
GTC has added Immunohistochemistry (IHC) testing to complement our next-gen sequencing capabilities. We can bring up an antibody or assay to use in your research project. Our NGS can also do a comparison of the IHC and NGS findings.
Capabilities include:
- Histology
- Custom IHC
- Image analysis
AI Algorithms
GTC offers several world class AI software’s available for your research and clinical trial projects with multiple publications in top journals. Our AI tools can assist with:
- Picking the correct cut offs for biomarkers
- Identify responders from non-responders
- Other critical testing algorithms
Our AI software’s can be customized and tuned to work with any assay
Customized Assays
Genomic Testing Cooperative (GTC) offers all types sequencing services for research projects and clinical trials. We provide a wide range of capabilities from Sanger sequencing to next generation sequencing. All projects are performed in our CAP and CLIA accredited laboratory by Clinical Laboratory Specialists (CLS).
We can provide several standard tumor profiling panels or we can collaborate on custom panel development for projects in the field of oncology and immuno-oncology. All studies have optional bioinformatics support and access to our deep learning tools or GTC can deliver raw data files for interpretation with your own tools.
Types of Pharma and Research Support Services We Offer:
- Next-gen sequencing
- Sanger sequencing
- RNA-analysis
- Solid tumor research
- Hematology research
- Liquid biopsy
- Custom assay development
- AI analysis
- Bioinformatics support
- CDx development
- Biomarker discovery
Standard panels we have validated:
- Solid Tumor Profile
- Solid Tumor Expression Profile
- Solid Tumor Profile Plus
- Liquid Biopsy Solid Tumor
- Hematology Profile
- Liquid Biopsy Hematology Profile
- Hematology Fusion Expression Profile
- Hematology Profile Plus
- Clonal Hematopoiesis
- For projects in other focus areas we can collaborate with you on your project.
GTC has a collaboration agreement in place with laboratories to perform IHC and flow cytometry and can perform additional services and capabilities beyond sequencing if your project requires it.